Mannogem® Mannitol Supplier & Distributor

More flexibility for formulators with lower total production costs!

Mannitol is a popular excipient used by drug manufacturers due to its unique, advantageous properties. It is inert, non-hygroscopic, and has high drug loading capabilities. Mannitol is also preferred for patients because it has a higher tolerance than alternatives such as lactose and fructose and mannitol has no impact on blood glucose levels, making it especially suitable for diabetic patients. SPI Pharma is the expert on mannitol and has recently increased their product offering with the addition of new Mannogem^® grades to offer drug manufacturers even more options.

Types available

Powder
Spray Dried
Granular
Co-processed

Formulation Benefits

Better binding and tabletability
Higher API loading capability
Improved throughput of difficult to manufacture tablets
Higher manufacturing productivity with wider design space

Monographs Available

U.S. Pharmacopeia (USP)
National Formulary (NF)
European Pharmacopeia (EP)
Japanese Pharmacopeia (JP)

Patient Benefits

Pleasant mouthfeel
Faster disintegration
Softer texture in chewable tablets
No impact on blood glucose levels

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Mannogem^® XL Technology improves compressibility and adds functionality

Mannogem^® XL Technology combines SPI Pharma’s mannitol expertise with proprietary processing and advanced particle engineering. The result is compendial mannitol with a ground-breaking improvement in tableting. The superior functionality against standard grades of directly compressible (DC) mannitol (including increased tensile strength and improved friability) opens up new formulation possibilities – it works well with taste-masked APIs and enable advanced dosage forms like multiple unit particle systems (MUPS). XL Technology brings additional value to drug manufacturers by improving production with a broader design space, higher yields, and faster production speeds. Mannitol produced with XL Technology also enhances the patient experience with better organoleptics to increase patient adherence.

Products

Mannitol Type	Mannogem^® Grade	Avg. Particle Size	Approx. Relative Compressibility	Manufacturing Process	End Use Applications	Monographs	Package Size
Powder	Emerald**	25 µm		Wet granulation	Tablets (swallow), liquids	USP-NF, EP	25 kg drum
Powder	Onyx**	50 µm		Wet granulation	Tablets (swallow), liquids	USP-NF, EP	25 kg drum
Spray Dried	EZ	140 µm	•••	Direct compression	Tablets (swallow, chewable, ODT, effervescent), hard capsules, lozenges, sachets/stick packs	USP-NF, EP	50 kg drum
	XL*	140 µm	••••	Direct compression	Tablets (swallow, chewable, ODT)	USP-NF, EP	25 kg drum
	XL Opal**	160 µm	••••	Direct compression	Tablets (swallow, chewable, ODT)	USP-NF, EP, JP	25 kg drum
Granular	XL Ruby**	300 µm	•••	Direct compression	Tablets (swallow, chewable, ODT, fast melt, TM, MUPS)	USP-NF, EP, JP	50 kg drum
	2080	320 µm	••	Direct compression	Tablets (swallow, chewable, effervescent), sachets/stick packs	USP-NF, EP	100 kg drum
	Granular	480 µm	••	Direct compression	Tablets (swallow, chewable, effervescent), sachets/stick packs	USP-NF, EP	100 kg drum
Co-processed (includes Mannogem^® mannitol)	Pharmaburst^® 500		••••	Direct compression	Tablets (ODT)	All ingredients are USP-NF	50 kg drum
	Pharmasperse^® 416			Dry blend	Sachets/stick packs (ODP)	All ingredients are USP-NF	50 kg drum
	Advantol^® 300		•••	Direct compression	Tablets (chewable, ODT, fast melt)	All ingredients are USP-NF	50 kg drum

*New in 2019!

**New in 2020!

Applications

Oral Solid Dosage Forms (OSDF)

Conventional swallow tablets, chewable tablets, orally disintegrating tablets (ODT), hard capsules, lozenges, effervescent tablets, sachets/stick packs (orally disintegrating powders/ODP), sublingual tablets, multiple unit pellet system (MUPS), liquid suspensions/syrups

Regulatory Information

Chemical name: D-mannitol
CAS number: 69-65-8
EC number: 200-711-8
REACH registration number: Not applicable
FDA Inactive Ingredient Database (IID) listed

Univar Solutions is the premier distributor of food ingredients in the USA

Vast network includes over 60 FDA-registered sites in the USA
Efficient private fleet with dedicated drivers servicing local regions
Partnership with world class food ingredient manufacturers
Experienced sales force with broad ingredient and food industry knowledge
Food scientists available to help customers through their new product development (NPD) cycles

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Security of Supply and COVID-19 Updates

Mannogem® Mannitol